Hi @tristan williams ,
The best practice is to only have the Hyper-V role installed on the server acting as a hypervisor, DFS Replication (DFS-R) is meant for replicating files and not virtual machines or databases. The .VHDX files of the virtual machines will also be in use which will complicate the DFS Replication.
Note that DFS Replication can have delays so it is definitely not optimal for virtual machines, if you want to replicate Hyper-V virtual machines you should consider Hyper-V Replica or any third-party replication, or storage replication.
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Leon