In general, upgrading from SFX1 to SFX2 should not affect the Skype for Business frontend services directly, as these services are separate from the Service Fabric Explorer. However, it's possible that the upgrade could cause some disruption or compatibility issues if there are dependencies or integrations between the two services. It's always a good idea to test any updates or upgrades in a non-production environment before implementing them in a live environment.
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