from ADO itself to Azure SQL DB should be fine If you do not have an app directly using 2014-04-01 API and if you only have " an Azure SQL database that accesses using ADO. NET in VB.NET 2022 then you are fine with this retirement.
Not sure about this customized setup. If you are using the latest .NET SDK, there will be no problem.
Please check this document for more information
we are updating the retirement doc to list all the client's version which needs to be replaced.