Using specific hardware with Hyper-V

Question

Is it possible with Hyper-V to use specific hardware on different VM's ?

Like 2 Graphics cards with each one assigned to a specific VM.

Also can you isolate the mobo onboard audio or pcie 1x audio card to one VM and on another only use an external USB/TB interface.

The intension is not to have both VM's running at the same time but rather to have them sandboxed from eachother without interfering with eachother
having one VM for every day work, webbrowsing etc. and the other for working with Audio editing.

Currently have a 16 core 5950 with 64Gb Ram and Win 10 Pro.