Hello@Mohamed Roushdy
Thank you for posting in our Q&A forum.
- Is there any error message when SA account and domain administrator account cannot open mscep_admin page?
- Is there a related event log?
Here are some similar cases for reference:
https://social.technet.microsoft.com/Forums/en-US/558e4b6b-27cb-4a74-9e31-6edeb09ffd9f/ndes-401-unauthorized-access-is-denied-due-to-invalid-credentials
https://knowledge.broadcom.com/external/article/155634/scep-server-shows-a-500-error-when-tryin.html
Hope above information can help you.
Best Regards,
Wesley Li