Instance Size Flexibility ratio comes into the picture when you have multiple VMs in the same VM family. However as in your case you have only one B4ms VM, you can directly buy 1 quantity of B4ms VM reservation which will cover this VM 100%.
Again, to get the maximum discount, it is recommended that you purchase reservation for all the VMs which has consistent usage 24/7 and you purchase the reservation of the same VM size.
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