Hi,
Yes, you need at least one of the 5 pre-requisite certifications to be Active in addition to MS-100 and MS-101. If your Microsoft 365 Certified: Security Administrator Associate (MS-500) is expired, then you need to pass it again or have one of the other 5 prerequisite certifications as shown on page below:
https://learn.microsoft.com/en-us/certifications/m365-enterprise-administrator/
If the above is unclear, please ask your question in the Microsoft Certification forum using link below. There are support moderators over there that will respond to your question in 1 business day and can assist:
https://trainingsupport.microsoft.com/en-us/newthread?threadtype=Questions&forum=mcp
Please click Accept Answer if above was helpful.
Thanks.
-TP