Hi, @luo gan
Thank you for posting in Microsoft Q&A forum.
It seems this issue occurs because the WSUS application pool in IIS "WsusPool" has reached its maximum private memory limit and attempts to recycle the memory usage.
You may follow the article to change the "Private Memory Limit (KB)" to "0" to set no memory limit, then restart IIS to see if it works.
https://www.stephenwagner.com/2019/05/14/wsus-iis-memory-issue-error-connection-error/
(Please Note: Since the website is not hosted by Microsoft, just for your reference.)
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