If you're going to work with Excel files, do yourself a favor and install the ImportExcel module (https://www.powershellgallery.com/packages/ImportExcel/7.0.1). You'll save yourself a lot of time and effort by not having to deal with the Excel application COM object.
Import-Excel -Path C:\junk\addr.xlsx |
ForEach-Object{
$e = Get-ADUser -Filter {emailaddress -eq $_.addr} -properties emailaddress
$status = "DISABLED"
if ($e){
if ($e.Enabled){
$status = "ENABLED"
}
Write-Host "$($e.emailaddress) is a(n) $status employee"
}
else{
Write-Host "$($e.emailaddress) is NOT an employee"
}
}