Microsoft provides a general document for troubleshooting
you can follow this one and if the problem still exists please try to provide more information about your environment, API etc.
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I have created a Azure bot and updated the Microsoft app id and password and also the secret key of direct line in the respective app service.
But I am getting error "There was an error sending this message to your bot. " while testing in Test in web chat and UI web app is not responding showing "unable to connect"
Microsoft provides a general document for troubleshooting
you can follow this one and if the problem still exists please try to provide more information about your environment, API etc.