Hi @Julian ,
Welcome to our forum!
if i remove key from registry, it's working.
I understand that the signature can work normally when you remove the registry key, what are your concerns?
in our company we force to use specific signature generate by a script.
Do you mean that you want to make the specific signature as default signature when you send/reply a email?
If so, as i know, we can do that directly in Outlook desktop client, just refer to the below image. It's suggested that you could try it.
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