A family of Microsoft server products that support large-scale implementation management of enterprise application integration processes.
SQL Server 2022 and Windows Server 2022 are supported as of CU6 for Biztalk 2020.
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Can we install BizTalk Server 2020 on Windows Server 2022 and use Sql Server 2022 as the default database?
A family of Microsoft server products that support large-scale implementation management of enterprise application integration processes.
Additional SQL Server features and topics not covered by specific categories
SQL Server 2022 and Windows Server 2022 are supported as of CU6 for Biztalk 2020.
See Hardware and Software Requirements for BizTalk Server 2020
Maximum windows version is Windows Server 2019
Maximum SQL version is Microsoft SQL Server 2019
So no, if you install on Windows Server 2022 and use SQL Server 2022 it won't be a supported configuration. It might work, but if you have any issues, Microsoft might decline support.