Hi @Kurt Stichelmans ,
Considering that you are using a "Mixed" environment and there might be multiple factors which will influence this issue, so I am trying to analyze this issue from the possible factors one by one.
In order to confirm if the issue is related to your Exchange email account itself, it is suggested for you to try the "OOF" feature from the web mail with those problematic email accounts and see if the error could be reproduced. If this issue can be reproduced on the web mail as well, the issue might be related to the email account itself. If everything can work fine on the web mail, I'm afraid that these Exchange account themselves are not the key point of this issue. (Personally I think, User B's email account can work fine in User A's Outlook, User B's email account itself should be fine.)
After excluding the account itself, we could continue to troubleshot this issue from the perspective of Outlook client, Windows or Citrix. Please kindly forgive me about not fully understand your operations mentioned here:
I change the profile path of user A to something else and after logging on I see it is another profile, opening Outlook gives me the wizard and then it opens Outlook. When I go to the autoreplies it gives me the error of not being available.
What exactly does the "profile path" you mentioned here mean? Windows profile or something else?
After your operations mentioned here, did you get this error again when logging in to the User B's mailbox? If so, it is suggested to continue to log into User A's mailbox and see if the issue has any difference.
According to your description, the issue could be reproduced on a working-fine device after your operations, so we might could be able to infer that this issue should be related to this specific operation or the changes that this specific operation leaded to. To conduct further researches on your issue, please try to provide me with more information related to this operation.
If you have any update about this issue, please feel free to post back.
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