Hi azhar1977,
Thank you for posting in the community.
Yes, it is possible to have different storage configurations on different nodes in a Windows Server 2022 failover cluster. However, it is important to note that this can add complexity to the cluster and may require additional configuration and management. Nodes in a failover cluster must share the same underlying storage in order to live migrate virtual machines between them in the event of a failover.
It is recommended to have a consistent storage configuration across all nodes in the cluster for ease of management and maintenance.