Apparently this has now been fixed in this month's update:
KB5044281 Windows Server 2022KB5044277 Windows Server 2019
KB5044293 Windows Server 2016
"**[Remote Desktop (known issue)]** Fixed: Windows Servers might disrupt Remote Desktop connections across your company. This issue might occur if you use a legacy protocol in the Remote Desktop Gateway. An example protocol is Remote Procedure Call over HTTP. If the issue occurs, it is sporadic, like every 30 minutes. At that point, you lose sessions that you are signed in to. Then you must reconnect to the server. IT admins can track this as an end to the TSGateway service. It stops responding, with the exception code 0xc0000005."
Can anyone confirm this update has fixed the issue for them?
I just installed this update to one of our client's servers that was affected by this issue. I will be monitoring the event log for the rest of the day and I will report back here if the issue still exists or if it is resolved.