Hi Raunak Agarwal,
For your AI startup, South India is the best primary Azure region since Azure OpenAI is unavailable in Central India, ensuring lower latency for India-based clients while remaining cost-effective. Co-locating Cosmos DB with OpenAI in South India is recommended to minimize query latency and data transfer costs. For GPU-based workloads (Phi-3), South India should be the first choice, but UK South or East US can serve as a backup due to potential GPU availability constraints.
A multi-region setup is advisable, with South India as primary and UK South as fallback, ensuring high availability and reduced latency for UK users via Azure Front Door or Traffic Manager. Cost optimization strategies include Azure Reserved Instances for GPUs, auto-scaling for FastAPI, and monitoring egress costs. If budget is a constraint, you can start with a single-region deployment in South India and scale to multi-region later as needed.
I hope this information helps. Thank you!