Now you can use Microsoft Graph/REST APIs in hybrid deployments is currently in preview. With Exchange 2016 Cumulative Update 3 (CU3), released in September 2016 for Exchange on-premises servers, adds support for REST API integration with Microsoft 365.
- If your app uses v1.0 of the Mail, Calendar, or Contacts API, you will now also find a seamless authentication and application experience in hybrid deployments, regardless of whether the mailbox is on-premises or in the cloud, provided that the deployment meets specific requirements.
- Only v1.0 of the Mail, Calendar and Contacts API are available for mailboxes in hybrid deployments. For more info, please refer.