IN RE 643 errors & .NET Framework updates:
First run the Fix It in this KB article & see if the update will install after doing so:
How to fix MSI software update registration corruption issues
http://support.microsoft.com/kb/971187
If no joy, see...
When installing updates using Windows update or Microsoft Update you may receive Error 0x643 or 0x80070643
http://support.microsoft.com/kb/976982
Then proceed per the following:
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Step #1 => Before doing anything else, write down what .NET Framework versions are currently installed:
How to determine which versions of the .NET Framework are installed and whether service packs have been applied
http://support.microsoft.com/kb/318785
[As of this post, KB318785 hasn't been revised since November 2008 so you may not find the pertinent information in it.]
Step #2 => Now see Resolution Method 2 in this related KB article: http://support.microsoft.com/kb/923100
After running the .NET Framework Cleanup Tool (not the discontinued Windows Installer Cleanup utility), reinstall all .NET Framework versions (but only the ones you wrote down in #1 above) manually using the download links on the page then run Windows Update manually to install security updates for same.
Download links for .NET Framework Cleanup Tool:
• http://cid-27e6a35d1a492af7.skydrive.live.com/self.aspx/Blog_Tools/dotnetfx_cleanup_tool.zip
NB: If you remove .NET Framework 3.5 (SP1) using the tool, reinstalling .NET Framework 3.5 will also install .Net Framework 2.0 SP2 and 3.0 SP2; then Windows Update will offer .NET Framework 3.5 SP1.
IMPORTANT! => If you remove .NET Framework 3.5 (SP1), reinstall your .NET Framework versions in the following order:
1. .Net Framework 3.5, then... 2. .Net Framework 1.1, then... 3. .Net Framework 1.1 SP1
NB: KB923100 references this page: http://blogs.msdn.com/astebner/archive/2006/05/30/611355.aspx. Please read ALL of it as well as the related page http://blogs.msdn.com/astebner/pages/8904493.aspx before using the .NET Framework Cleanup Tool.
Step #3 => Check-in at Windows Update and install any critical security updates offered.
~Robear Dyer (PA Bear) ~ MS MVP (IE, Mail, Security, Windows & Update Services) since 2002 ~ Disclaimer: MS MVPs neither represent nor work for Microsoft