Hi Nocturne_
My name is Andre Da Costa; an Independent Consultant, Windows Insider MVP and Windows & Devices for IT MVP. I'm here to help you with your problem.
Power on and off your computer three times
On the third time, your computer will boot into the Advanced Recovery environment
Click Advanced Options
Click Troubleshoot
Click Advanced Options
Click Startup Settings
Click Restart
Press (4) to Enable Safe Mode
Wait while Windows 10 starts in safe mode.
Log in
Press Windows key + X
Click Device Manager
Expand Universal Serial Bus controllers at the bottom
Right click each entry then click uninstall
Exit then restart
Windows 10 will then redetect them.
Check if they then work.
Additional troubleshooting steps:
Press Windows key + X
Click Device Manager
Expand Mice and other pointing devices.
Right click on the Mouse and click uninstall
Press Alt + F4
Press the Windows key + X
Press the letter U
Press the letter R
Restart in Normal mode and see if the mouse works.
It was an issue with the Synaptics drivers for my touchpad. I had to disable some Palm Check sensitivity, which I had read about a few days ago, but could not find the option.
OR
Press Windows key + X
Press the 'M' key
Press tab once
Use the down arround to select Mice and other pointing devices.
Press the right arrow to expand Mice and other pointing devices.
Use the down arrow again to select your HID-Compliant mouse
Press the right click menu key on your keyboard (usually located between the Alt and Control keys)
Select uninstall
Hit Enter
Press Alt + F4
Press the Windows key + X
Press the letter U
Press the letter R
Restart
Other things you can try.
Method 1: Run the Hardware and Devices troubleshooter. This troubleshooter finds and fixes common problems with devices on your computer.
Click Start.
Type Troubleshooting, and select Troubleshooting in the results.
In the new window, click Hardware and Sound.
In the list of options, click on Hardware and Devices.
Click Next and follow the on-screen instructions.
Method 2: Use the System File Checker tool to repair missing or corrupted system files. This allows users to scan for corruptions in Windows system files and restore corrupted files.
Open Start, type: CMD
Right click CMD
Click Run as administrator
Type in at the prompt OR Copy and Paste these one at a time : (Hit enter after each)
Dism /Online /Cleanup-Image /CheckHealth
Dism /Online /Cleanup-Image /ScanHealth
Dism /Online /Cleanup-Image /RestoreHealth
Also run the System File Checker utility:
Open Start, type: CMD
Right click CMD
Click Run as administrator
At the Command Prompt, type: sfc/scannow
This will check for any integrity violations
Restart your system