The alert indicates that Database Cache Percent Hit should be over 90%.
Please refer to this document: Mailbox Server Counters
It is about Exchange 2010 while also applies to Exchange 2016.
I suppose that the problem may be related to memory problems.
Can you find some related warning or error events in the event viewer>application log?
In addition, it is recommended to use the Exchange 2016 Server Role Requirements Calculator to calculate the required RAM and other hardware requirements for your Exchange server.
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