Hi @dirkdigs
What changes have been made on your server recently? Please check if Exchange server has high CPU usage
You could follow below suggestions to resolve this issue:
1.try to recycle the application pool "MSExchangeMapiFrontEndAppPool" from IIS Manager. IIS Manager > Application Pools > MSExchangeMapiFrontEndAppPool > Recycle

2.if not working, use the following cmdlet to reset IIS
iisreset /noforce
3.if not working, also try rebooting your sever
You may also check if the Microsoft Exchange Transport service and other transport related services are running properly on your server, we could restart them manually.
Some related official document about eventid 5011 for your reference as well:
Event ID 5011 — IIS Application Pool Availability
IIS Application Pool Crash and Debug Diag
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