Hello @C1TonyB ,
Adobe created an ActiveX control for IE, which allows Acrobat/Reader to open PDF files in an application(Adobe Acrobat Reader).
Adobe also provides a Chrome plugin control for the Chrome(which should also work with Edge), which allows users to open PDF files in desktop application under the right circumstances.
However, the Office Online Server opens the PDF files as Word documents, the plugin control will not working.
Thanks,
Echo Du
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