Hi
It happened to me, it was not related to DFS, but I think a patch or KB introduced that problem.
I have the same symptom as you, a user X work on a document, and when hitting save the security of the file just disappear. It block the save from Excel/Word, and it ask for another file name.
On the share I removed the entry CREATOR OWNER. It remove the full access they got on the file when they save it. It seem to have solved the issue, but I found that strange as it was working good the same client with file on like a 2008R2.
So I suggest to try that to solve the issue while Microsoft find a cause to this bug.
Thanks
Philippe