A family of Microsoft presentation graphics products that offer tools for creating presentations and adding graphic effects like multimedia objects and special effects with text.
Hi, I only came across the same issue very recently. If you haven't already resolved it already, try this...worked in my situation.
If videos play in edit mode but fail to play in Slide Show...
The Slide Show ‘Hardware Acceleration’ option MUST BE DISABLED (check-box ticked) in PowerPoint Advanced Options. The video will then work in Extended mode using Presenter View! The click-route is below…
PowerPoint 2016>File>Options>Advanced>Display>Disable Slide Show hardware graphics acceleration (ticked)
I must credit a fellow audio-visual professional technician for suggesting this...
All the best...