Hi HallieGromek,
Based on your description, we'd like to check whether you want to create an external domain iframe into SharePoint Online or connect SharePoint Online wikipage to the external domain.
If you want to create an external domain iframe into SharePoint Online, you can go to Site Settings > Site Collection Administration > HTML Field Security to change the permission to allow external iframes.
For more information, you can refer to this article: Allow or disallow iframes for a site collection.
[Updated by Tisky Zheng MSFT, 07:38 AM, Jun 14, 2017(UTC)]
Regards,
Tisky
Permit contributors to insert iframes from any external domain into pages on this site.