Hi @IBRAHIM SALEM ,
Based on your description, the OAB URI changed automatically to blank or something( sorry your picture was not loaded correctly).
I think you could remove the OAB virtual directory and re-create one. Re-creating OAB or doing something with the OAB itself is not related with this issue.
Remove-OabVirtualDirectory -Identity "Server1\OAB (Default Web Site)"
New-OABVirtualDirectory -Server Server1 -InternalUrl Https://server1.domain.com/oab -PollInterval 480
For more details, please refer to: https://learn.microsoft.com/en-us/powershell/module/exchange/new-oabvirtualdirectory?view=exchange-ps
If this doesn't work and the URI changes the next day, please check if your security softwares(windows defender or others) has virus detected.
And also if your Exchange is not the newest one, please consider a upgrade: https://techcommunity.microsoft.com/t5/exchange-team-blog/released-july-2021-exchange-server-security-updates/ba-p/2523421
Best regards,
Lou
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