When conditional formatting is applied to a range like a column and relative addressing is used, the formula entered should be as if only applying to the first cell of the "Applies to" range.
Example: If the "Applies to" range is column C, then the first row in any formula will be 1 so row 1 is used in the formula for Conditional Formatting. Most times when applying the formula to the cells of row 1, it will be the column headers and generally they will not meet the criteria so no problem. If the column headers are a problem because they will meet the criteria, it might be necessary to make the "Applies to" range from row 2 and down to whatever row is required and then the formula is applied as if C2 is the first cell. Excel applies the formula in the relative format to the remaining cells in the column.
If still having problems, then please post a screen shot of the data and explain what ranges need to be formatted and what condition must be met to apply the formatting. (If any sensitive data like people's names in the data, then make a copy of the worksheet and replace sensitive data with dummy data like Name 1, Name 2 etc.
Tip for screen shots. Ensure that you include the column headers and row numbers, even if it means you need to hide some rows and columns to make the screen shot viable for size.