Hello Erwin B,
First of all, I would recommend to try the Windows Driver Verifier tool:
Second, check the USB and Hard Drive power settings in the current power plan, by accessing Power & Sleep settings > Advanced > Edit Power plan. It should be set to not disable or not set to sleep after X minutes.
Third. Try a "full" reboot: Hold your Shift key, then click on the start menu and "Power Off". This turns off Windows 10 machines (like a button shutdown in previous versions) reloading all drivers and services.
Fourth: Reinstall the Generic USB and USB host devices in Device Manager. From Device Manager, select this devices with RightClick and select Uninstall. Reboot. This will force the load of latest versions installed on the system.
Last but not least I would suspect of some 3rd security software installed on the system, but highly depends on your deployment. I would suggest to disable 1 by 1 these systems (if any) to check which one is affecting. Then checking its configuration.
Hope it helps in your case!