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Thank you for your reply and patience while I investigated the issue with the "Trust sender" and "Show blocked content" buttons not working in Outlook Web App (OWA).
As a moderator, I’ve tested this issue in my own environment and tried my best to reproduce what you’re experiencing. When I open an email from a sender who isn’t on the Safe Senders list, those two buttons show up. But when I click them, nothing seems to happen, and there’s also no feedback or visible change.
However, after I refresh the page and go back to the email, the buttons disappear, then I noticed the sender is automatically added to the Safe Senders list.
So, even though it looks like the buttons aren’t working, the action is actually happening in the background. Could you please check your own Safe Senders list in Outlook Web App to see if the sender has been added after you click the button and refresh?
Based on this, it seems like a bug or UI glitch in the Outlook Web App interface. However, accessibility and user experience are priorities, I strongly encourage you to share your experience through Help > Feedback in the Outlook app or by visiting Microsoft Feedback Portal.
If my response was helpful, even in part, I’d be grateful if you could mark it as the Accepted Answer. It helps other affected users find this thread more easily and acknowledges the support you received.