Hi @CatherineG
Thank you for reaching out to the Microsoft Q&A Forum.
I understand how stressful it can be when Outlook 2016 can no longer open and reports that the .ost file is corrupt, especially when you’re worried about losing your old emails and personal folders.
Please note that Outlook 2016 has reached the end of support, so we cannot reproduce the issue in our test environment. However, I’ll do my best to assist you based on the available information.
To better understand your situation and provide more accurate guidance, could you please confirm whether your Outlook 2016 account is provided by Microsoft or by another mail service provider?
Since Outlook 2016 can no longer open properly, you might consider creating a new Outlook profile to check whether Outlook is able to start with a new configuration. You can find the detailed steps in this article: Create an Outlook profile - Microsoft Support
I look forward to your response.
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