It is generally not recommended to delete system folders like System 64 and Perflogs as they may contain important system files and logs that are necessary for Windows to function properly. Deleting these folders could lead to system instability or loss of functionality.
For MSI files, these are typically associated with Windows Installer packages. Deleting them may prevent you from uninstalling or updating applications that use these installers.
Mono is a framework used for running applications developed with .NET. If you are not using any applications that depend on Mono, you may consider removing it, but ensure that it is not required by any of your installed applications.
To free up space safely, consider using the Disk Cleanup tool or Storage Sense, which can help you identify and remove unnecessary files without risking the stability of your system.
References: