Update.
The test file that is executing which is a version of calc.exe with the MS digital signature stripped appears to be actually launching the built in calc.exe
So unless I'm mistaken the calc.exe (fake) in my downloads folder when executed launches the built in calc.exe The indication this is happening appears to be in the version numbers of the two different .exe's. It appears to be lunching from the downloads folder but it's actually launching the built in one, or appears to be at least. I've heard 'living of the land' techniques mentioned but I'm unfamiliar with that?
The second problem of how to use WDAC to block .exe's in the downloads folder completely is still also an issue.
Could anyone confirm whether blocking exe's in a folder is actually accomplishable with WDAC or would some other method be required?
I'm currently using Software Restriction Policies via Group policy but I'd rather abandon Group Policies in favour of something more current like WDAC.