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Hi @test_account
Thank you for reaching out to Microsoft Q&A.
Based on the information you shared, I understand that on a device running Access Runtime 2013 (32-bit) alongside Microsoft Office Home and Business 2019 (64-bit), the Access Runtime installer unexpectedly appears when opening an .accde file. This occurs intermittently (once every few months), is difficult to reproduce, and does not appear to be triggered by Windows Update. You have already attempted repairing the Runtime and troubleshooting MSACCESS.exe without success.
After researching this behavior, it appears that this is a conflict scenario when multiple Office installations with different bitness (32-bit and 64-bit) coexist on the same machine.
Currently, Microsoft does not support side-by-side installation of Office products with different bitness. When this configuration exists:
Each Office version writes and expects different registry keys and COM registrations. When an Access-based application is launched, Windows Installer may detect a mismatch
This triggers a self-repair/reconfiguration process, which appears as the Access Runtime installer. Because registry usage depends on which Office component ran most recently, the issue can appear intermittently, making it hard to trace.
This behavior has been widely reported as a registry and Windows Installer self-healing conflict, especially involving Access Runtime.
To prevent this behavior long-term, consider the following:
-Align the bitness: Use the same bitness for Office and Access Runtime (preferably 64-bit if Office is already 64-bit). This is the only fully supported and stable configuration.
-Recompile the ACCDE to match target bitness
When deploying a new Runtime, recompile the .accde using Access of the same bitness as the target machine (for example, compile with Access 64-bit if users run Office 64-bit). This avoids API / Declare issues and reduces re-registration conflicts.
The Access community generally recommends releasing applications in the same bitness as the customer environment.
I hope this explanation helps clarify both the cause and the resolution.
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