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As your description, it appears that your integration is calling the Create / Update Calendar Event API, and one specific user is encountering the following error:
"TimeZoneNotSupportedException A valid TimeZone value must be specified. The following TimeZone value is not supported: ''. "
This issue typically occurs when the start or end time of a calendar event contains a blank or unsupported timeZone field.
As suggested by the AI, you could try verify and correct the affected mailbox regional configuration in Exchange Online. A mismatched or unset time zone in the mailbox settings can cause this issue.
Use the following commands in Exchange Online PowerShell via:
Get-MailboxRegionalConfiguration -Identity <user>
To set a valid time zone, run:
Set-MailboxRegionalConfiguration -Identity <user> -TimeZone "<Your Time Zone>"
Reference:
Set-MailboxRegionalConfiguration (ExchangePowerShell) | Microsoft Learn
I hope this helps.
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