Hi @Luke Wildeman,
Thank you for reaching out to the Microsoft Q&A forum. Based on the details you shared, this behavior appears to be related to Microsoft Word for Microsoft 365 Version 2601 (Build 16.0.19628.20166). The issue has been observed when users open .docx files directly from a network drive (on-premises file server) by double-clicking the file. In this scenario, Word may crash during startup and subsequently prompt to open in Safe Mode. I have confirmed the following:
- The issue occurs only on Version 2601 (Build 16.0.19628.20166).
- Rolling back to an earlier version (for example, Version 2512) resolves the issue.
- As a temporary workaround, opening Word first from the Start menu and then opening the file from within Word prevents the crash.
- At this time, the issue is not documented as a known issue in the official Current Channel or Current Channel (Preview) release notes.
This strongly suggests a regression issue in this specific build, potentially related to how Word initializes when opening files from network locations. I recommend trying the following steps in order:
1. Disable Word add-ins (for testing)
- Open Word → File → Options → Add-ins
- Manage: COM Add-ins → Go
- Disable all add-ins, then restart Word
- Test opening a document directly from the network drive (If this resolves the issue, add-ins can be re-enabled one by one to identify the cause.)
2. Add the network location to Trusted Locations
- Word → Options → Trust Center → Trust Center Settings
- Trusted Locations → Add new location
- Add the network path (UNC or mapped drive) and allow subfolders
3. Temporarily test Protected View settings
- Word → Options → Trust Center → Trust Center Settings → Protected View
- Temporarily disable Protected View options and test again (This is for troubleshooting only and not recommended as a permanent configuration.)
4. Test UNC path versus mapped drive
If the file is currently opened from a mapped drive (for example, Z:), please test opening the same file using the UNC path (\ServerName\Share\File.docx).
5. Temporary mitigation
- Continue using one of the following until a permanent fix is available:
- Open Word first, then open the document from within the application
- Remain on a previous stable version (such as Version 2512)
If the issue continues after these steps, the next recommended action would be to engage Microsoft Support so that a technical support engineer can review crash logs, verify backend behavior, and escalate the case if required.
How to Submit the Support Ticket in Admin Center: Get support - Microsoft 365 admin | Microsoft Learn
Please let me know the results after testing the above steps, or if you have any questions or concerns. I will be happy to assist further.
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