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Hello Istok Ferjan,
Thank you for reaching out to Microsoft Q&A. I'm sorry to hear you're experiencing issues with outbound email from your hospital's being blocked. This is often due to detected suspicious activity, such as potential spam, but it can usually be addressed through Microsoft's self-service delisting process. As the IP appears to be on an internal block list, as a forum moderator, I can't unblock it directly. Microsoft's security policies require the request to come from an authorized party via the official portal to prevent abuse. As Q&A assist has mention, you can go to the Office 365 Anti-Spam IP Delist Portal at https://sender.office.com. Microsoft typically reviews these within a few hours, but approval depends on no ongoing issues like malware or policy violations. If approved, the block should lift shortly after.
Alternative, you could ask the recipient to Whitelist Your IP:
If the block is only affecting one organization (or a few):
Ask their Microsoft 365 admin to add your IP to their IP Allow List:
Microsoft Defender portal → Policies & rules → Threat policies → Anti-spam policies → Connection filter policy (default) → Edit → IP Allow List → add the IP.
This skips EOP filtering for mail from your server to that tenant only.
Hope this help.
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