Hi @William Mason,
Welcome to Microsoft Q&A forum.
Thank you for providing those details. It is common for input devices to experience configuration "hiccups" immediately after a PC wakes from sleep mode.
To resolve this behavior and restore your mouse’s standard functionality, please try the following steps:
1/ Verify primary button configuration
It is possible that the primary button assignment was inadvertently swapped in your system settings.
- Navigate to Settings > Bluetooth & devices > Mouse.
- Ensure the Primary mouse button is set to Left.
- Alternatively, open the Control Panel, go to Mouse > Buttons, and ensure the "Switch primary and secondary buttons" checkbox is unchecked.
2/ Reconnect the hardware
If you are using a wired or wireless USB mouse, unplug the device or dongle, wait a few seconds, and reconnect it. Testing a different USB port can help rule out a connection error triggered by the power state change.
3/ Update or reinstall drivers
If the buttons remain reversed, the driver may have failed to initialize correctly after sleep.
- Open Device Manager, right-click your mouse under Mice and other pointing devices and select Update driver.
- If no updates are found, select Uninstall device and restart your computer. Windows will automatically reinstall the driver upon reboot.
4/ Check Device-Specific software
If you are using a specialized mouse (such as a Microsoft, Logitech, or Razer device), please check the manufacturer's dedicated software (e.g., Mouse and Keyboard Center) to ensure no custom profiles were activated.
In case the problem persists, could you clarify a couple of details?
- Are the buttons swapped (left-click acting as right-click), or is the cursor movement reversed (e.g., moving the mouse up moves the pointer down)?
- Is the device connected via USB or Bluetooth?
Hopefully, this resolves the issue. Please let me know if you need further assistance!