Hello @MantaRay - Sorry for the delayed.
I checked previous such queries and S2D is not supported for hybrid scenarios – so both VMware or Hyper-V protections don’t support S2D. S2D on guest machine is not supported as we already call that out in our documentation here - https://learn.microsoft.com/en-us/azure/site-recovery/hyper-v-azure-support-matrix#hyper-v-vm-guest-storage.
Please reply if you have further questions in this matter!
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