Hi SAGA,
Yes, if you set the RC4DefaultDisablementPhase registry key before April, it will still take effect after the April patch once the domain controller is rebooted. The enforcement only applies after restart, so the key will successfully postpone RC4 disablement until July. The key must be placed under HKLM\SYSTEM\CurrentControlSet\Control\Lsa\Kerberos\Parameters and present before the patch is applied.
For the applications side, mitigation means they must stop relying on RC4 and move to AES. That requires updating service accounts and applications so their Kerberos accounts have msDS-SupportedEncryptionTypes set to include AES128 and AES256. Legacy systems or appliances that cannot negotiate AES will need vendor updates or reconfiguration. In short, your registry key buys time until July, but the apps team must ensure Kerberos tickets are issued with AES before the grace period ends.
I hope you found something helpful here. If it does help to explain your question, please accept the answer, or give it a thump up to encourage my contribution. Thank you.
Harry.