Hello, thank you for reaching out to Microsoft Q&A.
If the USB drive is empty, you can format the disk.
Open the command prompt as Administrator. Run these commands one by one and click Enter for each command.
diskpart
list disk
select disk X
clean
create partition primary
select partition 1
active
format fs=ntfs quick
assign
exit
Replace X with the thumb drive disk letter.
=================================================================
If there are any important files on the disk and you don't want to format it, just share a screenshot of the error message you get when you try to access the thumb drive.