Hi @Ashwan ,
What are the error you get? Please check your error log.
Your question may have something to do with TLS. I found a similar case and discussion by others: https://dba.stackexchange.com/questions/213608/enable-tls-1-2-for-sql-server-2016-database-mail
Perhaps the 2 new registry settings here can fix your problem:
Windows Registry Editor Version 5.00
[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\.NETFramework\v4.0.30319]
"SchUseStrongCrypto"=dword:00000001
[HKEY_LOCAL_MACHINE\SOFTWARE\Wow6432Node\Microsoft\.NETFramework\v4.0.30319]
"SchUseStrongCrypto"=dword:00000001
And if you enable TLS 1.2 for SQL Server communication, the following registry you should set correctly:
[HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Control\SecurityProviders\SCHANNEL\Protocols\TLS 1.2]
[HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Control\SecurityProviders\SCHANNEL\Protocols\TLS 1.2\Client] "DisabledByDefault"=dword:00000000 "Enabled"=dword:00000001
[HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Control\SecurityProviders\SCHANNEL\Protocols\TLS 1.2\Server] "DisabledByDefault"=dword:00000000 "Enabled"=dword:00000001