I had several Excel macros in PERSONAL.xlsb and for years have been able to use them with no problem. A couple of times in the last couple of weeks, I would receive an error message saying there was a problem trying to load them when starting Excel. I would exit Excel and try again, no problem and macros were available. Yesterday they were available at the start of the day but in the evening they no longer were. I tried the various suggestions identified online, such as checking Trust Center, etc. Everything checked out. Finally I moved PERSONAL.xlsb to another location, restarted Excel, created a meaningless macro to be stored in a new PERSONAL.xlsb which Excel would create. Exited Excel, clicked on the new PERSONAL.xlsb to open it, unhid it, alt-F8 to bring up a list of macros, and it's there. Exited Excel, restarted Excel (not by clicking on a spreadsheet), clicked on the blank-workbook option. Alt-F8 shows does not show the new macro, implying PERSONAL.xlsb was not opened. PERSONAL.xlsb still in XLSTART. Moved it to another location. Copied original PERSONAL.xlsb back to XLSTART, renamed it to PERSONAL1.xlsb. Restarted Excel, blank workbook (also happened if I opened a .xlsm file), alt-F8 now shows all the macros in PERSONAL1 (since it was in XLSTART, Excel would open it also) as well as the .xlsm file opened, but not the one in the new PERSONAL.xlsb. Why won't Excel open PERSONAL.xlsb? I can obviously get around the problem, just have to be careful if creating a new macro that I want to make available thru XLSTART.