Hello Evgenii,
Thank you for your detailed description. I can also see that you have already performed a number of troubleshooting steps.
May I ask if you have another Windows user profile on the PC?
If not, kindly create a new local administrator account and check whether Windows Defender opens correctly from the new profile.
You can use these steps through settings
https://support.microsoft.com/en-us/windows/manage-user-accounts-in-windows-104dc19f-6430-4b49-6a2b-e4dbd1dcdf32
To create a new user profile using Netplwiz
Press Windows + R, type netplwiz, and press Enter.
Click Add.
- Select Sign in without a Microsoft account (not recommended).
- Click Local account.
- Enter a username and password, then click Next and Finish.
- Back in the User Accounts window, select the newly created account and click Properties.
- Open the Group Membership tab and select Administrator.
- Click Apply and OK.
- Sign out of your current account and sign in to the newly created account.
- Try launching Windows Defender.
Kindly respond whether the issue persists in the new profile. This will help determine whether the issue is profile-specific or system-wide.
We look forward to your update so we can assist you further in resolving this issue.