Windows randomly go unresponsive to mouse clicks on Windows 11

Question

Hello everyone, I built my gaming computer about a year ago and transferred my m.2 from my previous laptop to this one, if that helps. I've had this problem since I built it that sometimes, applications and even the file explorer make a sound when I click on them and they don't respond to clicks. They do seem to know the mouse is there and that it's hovering over certain icons, but clicking simply doesn't work. Keyboard presses do work. The only solution I've found thus far is to restart every application that does this, which gets annoying because it happens often, and commonly multiple windows at the same time will do this. Anyone got a solution? Thanks in advance.

Answer 1

Hi Korbin Grimes,

I understand how frustrating this can be, especially when multiple applications stop responding to mouse clicks and require frequent restarts.

First, please let me know:

• Your motherboard model
• Whether the issue occurs with all mice or only one
• Whether affected applications are games only, or also regular applications such as File Explorer, Notepad, and web browsers

In the meantime, please try the following:

1, Open Command Prompt (Admin) and run the following commands one at a time:

DISM /Online /Cleanup-Image /RestoreHealth
sfc /scannow

Restart the PC after both commands complete.

2, Check whether you are running the latest chipset drivers for your motherboard. Download them directly from the motherboard manufacturer's support page rather than relying only on Windows Update.

3, Perform a clean boot to determine whether a third-party application is interfering with Windows input handling: How to perform a clean boot in Windows.

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