Hi @Imran Jalali ,
No, you can't.
Sharepoint 2019 CSOM doesn't supoort .NET Core. Only .Net framwork is supported. You could refer to this article: https://learn.microsoft.com/en-us/sharepoint/dev/sp-add-ins/using-csom-for-dotnet-standard#key-differences-between-the-net-framework-version-and-the-net-standard-version
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