This occurs because in 2016, opening in client directly requires an ActiveX control which is IE-only. Your options are to tell users to explicitly select open in client, open in client after opening in Word Online, removing the WOPI binding for docx, or removing Office Online Server WOPI binding altogether.
Sharepoint 2016 : New document creation opens in Word Online in Edge and Chrome despite Open in Client application setting
Akshatha KS
26
Reputation points
New document creation opens in Word Online in Edge and Chrome despite Open in Client application setting configured at the library level.
This works fine on Internet explorer though. What could be the issue? Urgent as customer is due for Production soon.
2 answers
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Trevor Seward 11,681 Reputation points
2020-09-08T18:38:13.627+00:00 This issue may be addressed in this month's patches. You must apply both patches.
https://support.microsoft.com/help/4484512
https://support.microsoft.com/help/4484506