Hi @Neil Benson
Is your environment a cloud only one, no on-premsies Exchange server?
Have you tried using other browser and private mode to access OWA? Do you have other admin roles for this account, if yes, remove them temporarily and only keep Global Administrator.
In addition, you could also check the Service health in your admin portal to see if any issue occurs
https://admin.microsoft.com/Adminportal/Home?source=applauncher#/servicehealth
If the suggestions above are helpful to you, it's also suggested to open a service request to o365 backend to get further information what may caused this issue: Get support
If an Answer is helpful, please click "Accept Answer" and upvote it.
Note: Please follow the steps in our documentation to enable e-mail notifications if you want to receive the related email notification for this thread.