I wouldn't to that for business server. These days RDP alone is not secure enough. I would suggest to put VM with RDP in private network (in Azure) and VPN gateway: https://learn.microsoft.com/en-us/azure/vpn-gateway/vpn-gateway-about-vpngateways.
First, you authenticate on VPN (which is harder to break/exploit assuming that you use strong passwords) enter backend network and then do RDP to your business VM.
You accept possible risks while keeping current configuration (direct RDP). I would recommend to reduce these risks by adding extra protection layer.
I fully agree with @Vadims Podāns !
The argument "the last 3 years there was no braking issue" doesn't mean anything. "No licensed anti virus on the computer" doesn't make it any better ;-)
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Regards
Andreas Baumgarten