Hi, many thanks for your answer.
The certificate is properly installed. As I wrote in my question, in "my" replication system there are about 100 subscribers that are regularly replicating. But they are all SQL 2008 R2 Express subcribers.
I have such problem only in this new client environment, where i've installed SQL 2019 Express.
The exact error that the client receives is:
SQL Server Network Interfaces: Error Locating Server/Instance Specified [xFFFFFFFF].
A network-related or instance-specific error has occurred while establishing a connection to SQL Server. Server is not found or not accessible. Check if instance name is correct and if SQL Server is configured to allow remote connections
In my opinion, this is a proof that the client is ignoring the "Web Synchronization" option and that is trying a merge replication against the database server.
Besides, if i set a wrong and not-existing URL for the InternetUrl of the Subcription object (in my C# class), the error message doesn't change .... so the client is not trying to reach the web server, otherwise I should receive a different error.
Thanks
Stefano Busolin