Hi Jon,
From the description, I understand that sending Office 365 account has been banned due to detected spam activity.
I would like to know whether you are Office 365 admin. If not, please contact your admin to unblock your blocked Office 365 email account via using Exchange admin center.
• Go to the EAC, navigate to protection > action center.
• Select the Search icon and enter the SMTP address of the blocked user.
• Click Unblock Account in the description pane.
• Click Yes to confirm the change.
For more detailed information, please refer to the article: Removing a user, domain, or IP address from a block list after sending spam email
If you still having problem or need assistance, please provide us with the detailed NDR and tenant information via the Private Message so that we can report to the relevant team and further assist you.
Your time and understanding will be highly appreciated.
Best regards,
Shyamal